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M9460585.TXT
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1994-06-25
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Document 0585
DOCN M9460585
TI Pathogenesis of SIVmac infection in Chinese and Indian rhesus macaques:
effects of splenectomy on virus burden.
DT 9408
AU Joag SV; Stephens EB; Adams RJ; Foresman L; Narayan O; Department of
Microbiology, Marion Merrell Dow Laboratory of; Viral Pathogenesis,
Kansas University Medical Center, Kansas City; 66160-7424.
SO Virology. 1994 May 1;200(2):436-46. Unique Identifier : AIDSLINE
MED/94233707
AB The spleen and lymph nodes are the predominant sites of viral
replication in SIV and HIV infections. We studied splenectomized and
control unsplenectomized rhesus macaques of both the Indian and the
Chinese subspecies of Macaca mulatta. All animals were inoculated with
SIVmac239, a molecularly cloned strain of SIV. Our data showed: (1)
splenectomized animals, particularly among the Indian subspecies, had a
lower virus burden and longer survival than unsplenectomized controls,
(2) the Chinese macaques controlled virus replication more effectively
than did the Indian animals, and (3) that a higher infectious virus
burden was present in LN/spleen than in blood in both splenectomized and
control animals.
DE Animal Antigens, CD8/IMMUNOLOGY Base Sequence China Disease
Susceptibility Immunity, Cellular India Leukocytes,
Mononuclear/MICROBIOLOGY Lymph Nodes/CYTOLOGY/*MICROBIOLOGY Macaca
mulatta/*MICROBIOLOGY Molecular Sequence Data Polymerase Chain
Reaction Simian Acquired Immunodeficiency Syndrome/*ETIOLOGY Species
Specificity Spleen/CYTOLOGY/*MICROBIOLOGY Splenectomy Support, U.S.
Gov't, P.H.S. Survival Analysis SIV/ISOLATION & PURIF JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).